Gut

Fibroblast pentose phosphate pathway activation upon decreased circPLCE1 exacerbates intestinal fibrosis in Crohn’s disease

Background Intestinal fibrosis, a hallmark complication of Crohn’s disease (CD), frequently progresses to stricture formation ...
gut.bmj

Fibrosis in IBD: from pathogenesis to therapeutic targets

Background Intestinal fibrosis resulting in stricture formation and obstruction in Crohn’s disease (CD) and increased wall stiffness leading to symptoms in ulcerative colitis (UC) is among the largest ...
gut.bmj

Yin Yang 1 promotes hepatic steatosis through repression of farnesoid X receptor in obese mice

1 Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 2 Genomic ...
gut.bmj

Acute appendicitis is characterised by local invasion with Fusobacterium nucleatum/necrophorum

Background Acute appendicitis is a local intestinal inflammation with unclear origin. The aim was to test whether bacteria in appendicitis differ in composition to bacteria found in caecal biopsies ...
Gut

Response to ‘Rectal versus colonic submucosal cancer rates and procedural outcomes in large non-pedunculated polyps: French ESD registry data’

We read with great interest the study by Van der Voort et al ,1 which compared rectal versus colonic submucosal cancer rates ...
GutOpinion

Red cells, red flags: are we harming stable patients with outdated transfusion thresholds?

The 2022 UK-wide acute upper gastrointestinal bleeding (AUGIB) audit by Nigam and colleagues is a landmark. With ...
gut.bmj

Behaviour of Crohn's disease according to the Vienna classification: changing pattern over the course of the disease

BACKGROUND Crohn's disease is a heterogeneous disorder with both a genetic and environmental aetiology. Clinical classifications of the disease, such as the newly proposed Vienna classification, may ...
gut.bmj

Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer

1 Department of Medicine A, Ernst-Moritz-Arndt Universität Greifswald, Greifswald, Germany 2 Department of Surgery, Ernst-Moritz-Arndt Universität Greifswald, Greifswald, Germany 3 Department of ...
gut.bmj

Oral contraceptives, reproductive factors and risk of inflammatory bowel disease

1 Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA 2 Division of Gastroenterology and Nutrition, Children's Hospital Boston and ...
gut.bmj

EUS versus MRCP to perform ERCP in patients with intermediate likelihood of choledocholithiasis: a randomised controlled trial

Objective In patients with an intermediate likelihood of choledocholithiasis, European Society of Gastrointestinal Endoscopy (ESGE) guidelines recommend endoscopic ultrasound (EUS) or magnetic ...
gut.bmj

Long-term liver-related outcomes and liver stiffness progression of statin usage in steatotic liver disease

19 Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore 24 Center for Digestive Diseases Research and Clinical Translation of Shanghai Jiao Tong University, Shanghai, ...
gut.bmj

Single-biopsy epigenetic profiling reveals persistent DNA methylation and gastric cancer risk after Helicobacter pylori eradication

Gastric cancer is a major global health concern, with ongoing efforts focused on screening and eradicating Helicobacter pylori infection.1 However, H. pylori infection is typically acquired during ...