You can also see the model's best bets for every Week 15 NFL game. Finally, SportsLine expert RJ White, who is 141-120-5 (+1421) over his last 266 NFL picks, has locked in multiple Week 15 NFL picks. Visit SportsLine to see his best bets.

USA Today's NFL experts make their picks for a Week 15 showdown between the San Francisco 49ers and Tennessee Titans

Week 15 of the NFL season is underway, and there are some key players dealing with injuries. Commanders star quarterback Jayden Daniels will return to the bench after re-aggravating a previous injury, while the Jets and the Raiders will roll out backup signal-callers.

SportsLine's model reveals its Week 15 Fantasy football projections, PPR rankings, start-sit advice for sites like CBS Sports, ESPN and Yahoo

The Browns and Bears are set for a frigid battle in NFL Week 15, and here are five bold predictions ahead of the matchup:

Notable odds: The Rams are essentially a lock to make the playoffs (97% odds on NFL.com), but they are still in a very tight race with the Seahawks and 49ers in the NFC West. The No. 1 seed isn't a lock by any means but the Rams are the favorites, per The Athletic's playoff odds, at 48%.

We've reached Week 15 of the 2025 NFL season, and while some teams aim to make late-season pushes into the postseason, others are keeping one eye on the upcoming NFL Draft and the other on their roster to see which players should and shouldn't return.