Accurate RNA splicing is essential for gene expression and human health, yet predicting how DNA sequence variations affect splicing remains a major challenge. Although recent artificial intelligence ...
Although heart cells and skin cells contain identical instructions for creating proteins encoded in their DNA, they're able to fill such disparate niches because molecular machinery can cut out and ...
Genes undergo extensive editing through a process called alternative splicing, which greatly increases the size of the functional genome—the working portion of our DNA that helps make each person ...
In 2024, two scientists from Google DeepMind shared the Nobel Prize in chemistry for an artificial-intelligence program called AlphaFold2. For decades, scientists had struggled to understand how ...
A hierarchical Transformer model analyzes DNA sequences spanning up to 100,000 base pairs, linking distant regulatory elements with splice-site activity while highlighting biologically important ...